Endocrine Abstracts

Endogenous Cushing’s syndrome (CS) causes a host of recognized physical and psychological complications, but the socioeconomic consequences of CS have not been as well-described. We recently conducted a comprehensive analysis of how patients’ socioeconomic factors change before diagnosis and after treatment compared to healthy controls. In a Danish nationwide cohort, patients with CS had lower rates of employment, lower income, delayed educations, and negatively affe...

Pheochromocytoma is a rare disease but frequently poses a diagnostic dilemma due to the unspecific symptoms and its potentially life-threatening nature. There is a perception of an increase in the incidence of pheocromocytomas in recent years, but no data on time trends exist. We obtained data from The Danish National Registry of Patients, The Danish Registry of Causes of Death, and The National Pathology Registry for all persons registered with pheochromocytoma in 1977–2...

Objective: Quantify classic and 11-oxygenated androgens in serum and saliva and determine variations across age, sex, body mass index (BMI), menstruation and hormonal contraception use.Methods: Morning serum samples were collected from 292 healthy volunteers (125 men, 22-95 years; 167 women, 21-91 years). Morning saliva was collected from 83 healthy volunteers (51 women, 32 men). 25 individuals (12 women, 13 men) also collected a 7-timepoint diurnal sali...

Introduction: Cushing’s syndrome (CS) results from prolonged glucocorticoid excess. Both iatrogenic and endogenous CS cause somatic and neuropsychiatric morbidity that do not fully reverse after biochemical disease control. However, the real-world socio-economic consequences for patients and their families are largely unknown.Aim: To determine the impact of CS on work status, income, education, marital status, parenthood, and depression before and ...

Background: Pheochromocytomas and catecholamine-secreting paragangliomas (PPGL) are rare catecholamine-producing tumors. Due to the rarity, limited data on prognosis exists and data are mainly from tertiary centers with potential referral bias. Here, we present population-based mortality data over an observation period of 40 years.Materials and methods: We identified a cohort of 198 PPGL patients diagnosed 1 January 1977 to 31 December 2016 in North and ...

Background: The gonads are the major source of classic androgens during reproductive years. Additionally, the adrenal gland produces precursors for both classic and 11-oxygenated androgen biosynthesis, with androgen activation predominantly occurring in peripheral target tissues of androgen action. We used liquid chromatography-tandem mass spectrometry to profile classic and 11-oxygenated androgens in serum and saliva across the adult age range and assessed diurnal as well as ...